Phosphoribosyl-ATP diphosphatase

In enzymology, a phosphoribosyl-ATP diphosphatase (EC 3.6.1.31) is an enzyme that catalyzes the chemical reaction

1-(5-phosphoribosyl)-ATP + H₂O ${\displaystyle \rightleftharpoons }$ 1-(5-phosphoribosyl)-AMP + diphosphate

phosphoribosyl-ATP diphosphatase
phosphoribosyl-ATP pyrophosphatase tetramer, Streptomyces coelicolor
Identifiers
EC no.	3.6.1.31
CAS no.	69553-55-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are 1-(5-phosphoribosyl)-ATP and H₂O, whereas its two products are 1-(5-phosphoribosyl)-AMP and diphosphate.

This enzyme participates in histidine metabolism. It employs one cofactor, H+.

Nomenclature

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is 1-(5-phosphoribosyl)-ATP diphosphohydrolase. Other names in common use include phosphoribosyl-ATP pyrophosphatase, and phosphoribosyladenosine triphosphate pyrophosphatase.