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Piketoprofen
Chemical compound From Wikipedia, the free encyclopedia
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Piketoprofen (INN; trade names Calmatel, Picalm) is a nonsteroidal anti-inflammatory drug (NSAID) for topical use in form of a cream.[1][2]
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Chemically, it is the 4-picolineamide of the NSAID ketoprofen.
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Synthesis
Thionyl chloride reacts with ketoprofen to form its acid chloride (2). Amide formation with 2-amino-4-methylpyridine (3) gives piketoprofen.[3][4]
References
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