Polygalacturonate 4-alpha-galacturonosyltransferase

In enzymology, a polygalacturonate 4-alpha-galacturonosyltransferase (EC 2.4.1.43) is an enzyme that catalyzes the chemical reaction

UDP-D-galacturonate + (1,4-alpha-D-galacturonosyl)n ${\displaystyle \rightleftharpoons }$ UDP + (1,4-alpha-D-galacturonosyl)n⁺1

polygalacturonate 4-alpha-galacturonosyltransferase
Identifiers
EC no.	2.4.1.43
CAS no.	37277-53-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are UDP-D-galacturonate and (1,4-alpha-D-galacturonosyl)n, whereas its two products are UDP and (1,4-alpha-D-galacturonosyl)n+1.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-D-galacturonate:1,4-alpha-poly-D-galacturonate 4-alpha-D-galacturonosyltransferase. Other names in common use include UDP galacturonate-polygalacturonate alpha-galacturonosyltransferase, uridine diphosphogalacturonate-polygalacturonate, and alpha-galacturonosyltransferase. This enzyme participates in starch and sucrose metabolism and nucleotide sugars metabolism.

Indications

Polygalacturonate salts can be used clinically to treat the GI reactions that are due to Quinidine.