DNA ligase (NAD+)

DNA ligase (NAD⁺) (EC 6.5.1.2, polydeoxyribonucleotide synthase (NAD⁺), polynucleotide ligase (NAD⁺), DNA repair enzyme, DNA joinase, polynucleotide synthetase (nicotinamide adenine dinucleotide), deoxyribonucleic-joining enzyme, deoxyribonucleic ligase, deoxyribonucleic repair enzyme, deoxyribonucleic joinase, DNA ligase, deoxyribonucleate ligase, polynucleotide ligase, deoxyribonucleic acid ligase, polynucleotide synthetase, deoxyribonucleic acid joinase, DNA-joining enzyme, polynucleotide ligase (nicotinamide adenine dinucleotide)) is an enzyme with systematic name poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming).^[1] This enzyme catalyses the following chemical reaction

NAD⁺ + (deoxyribonucleotide)_n + (deoxyribonucleotide)_m ${\displaystyle \rightleftharpoons }$ AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)_n+m

DNA ligase (NAD+)
Identifiers
EC no.	6.5.1.2
CAS no.	37259-52-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Catalyses the formation of a phosphodiester at the site of a single-strand break in duplex DNA.

See also

• DNA ligase