Potassium canrenoate

Potassium canrenoate (INN, JAN) or canrenoate potassium (USAN) (brand names Venactone, Soldactone), also known as aldadiene kalium,^[1] the potassium salt of canrenoic acid, is an aldosterone antagonist of the spirolactone group.^[2] Like spironolactone, it is a prodrug, and is metabolized to active canrenone in the body.^[3][4]

Potassium canrenoate

Clinical data
Other names	SC-14266
AHFS/Drugs.com	International Drug Names
Routes of administration	Intravenous
ATC code	C03DA02 (WHO)
Pharmacokinetic data
Metabolism	Hepatic
Excretion	Renal and fecal
Identifiers
IUPAC name potassium 3-[(8R,9S,10R,13S,14S,17R)- 17-hydroxy-10,13-dimethyl-3-oxo-2,8,9, 11,12,14,15,16-octahydro-1H-cyclopenta[a] phenanthren-17-yl]propanoate
CAS Number	2181-04-6 N
PubChem CID	23671691
DrugBank	DB09015 N
ChemSpider	570975 Y
UNII	M671F9NLEA
ChEMBL	ChEMBL1371200 N
CompTox Dashboard (EPA)	DTXSID2045602
ECHA InfoCard	100.016.868
Chemical and physical data
Formula	C22H29KO4
Molar mass	396.568 g·mol−1
3D model (JSmol)	Interactive image
SMILES [K+].[O-]C(=O)CC[C@]3(O)CC[C@H]2[C@@H]4/C=C\C1=C\C(=O)CC[C@@]1([C@H]4CC[C@@]23C)C
InChI InChI=1S/C22H30O4.K/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21,26)12-8-19(24)25;/h3-4,13,16-18,26H,5-12H2,1-2H3,(H,24,25);/q;+1/p-1/t16-,17+,18+,20+,21+,22-;/m1./s1 Y Key:JTZQCHFUGHIPDF-RYVBEKKQSA-M Y
NY (what is this?)  (verify)

Potassium canrenoate is notable in that it is the only clinically used antimineralocorticoid which is available for parenteral administration (specifically intravenous)^[4][5] as opposed to oral administration.^[6]

In the UK, it is unlicensed and only used for short term diuresis in oedema or heart failure in neonates or children under specialist initiation and monitoring.

See also

• Canrenoic acid
• Canrenone