Prenylcysteine oxidase

In enzymology, a prenylcysteine oxidase (EC 1.8.3.5) is an enzyme that catalyzes the chemical reaction

an S-prenyl-L-cysteine + O₂ + H₂O ${\displaystyle \rightleftharpoons }$ a prenal + L-cysteine + H₂O₂

prenylcysteine oxidase
Identifiers
EC no.	1.8.3.5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are S-prenyl-L-cysteine, O₂, and H₂O, whereas its 3 products are prenal, L-cysteine, and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with oxygen as acceptor. The systematic name of this enzyme class is S-prenyl-L-cysteine:oxygen oxidoreductase. This enzyme is also called prenylcysteine lyase.

Human protein and gene

• Prenylcysteine oxidase 1, symbol PCYOX1, gene on chromosome 2

See also

• Hemithioacetals in nature, for mechanism of action
• Flavin adenine dinucleotide, cofactor of the enzyme
• Prenylation, a process forming S-prenyl-L-cysteine