Progesterone 11alpha-monooxygenase

In enzymology, a progesterone 11alpha-monooxygenase (EC 1.14.99.14) is an enzyme that catalyzes the chemical reaction

progesterone + AH₂ + O₂ ${\displaystyle \rightleftharpoons }$ 11alpha-hydroxyprogesterone + A + H₂O

progesterone 11-alpha-monooxygenase
Identifiers
EC no.	1.14.99.14
CAS no.	37256-77-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are progesterone, AH2, and O₂, whereas its 3 products are 11alpha-hydroxyprogesterone, A, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is progesterone,hydrogen-donor:oxygen oxidoreductase (11alpha-hydroxylating). This enzyme is also called progesterone 11alpha-hydroxylase. This enzyme participates in c21-steroid hormone metabolism.