Proline—tRNA ligase

In enzymology, a proline—tRNA ligase (EC 6.1.1.15) is an enzyme that catalyzes the chemical reaction

ATP + L-proline + tRNAPro ${\displaystyle \rightleftharpoons }$ AMP + diphosphate + L-prolyl-tRNAPro

Proline—tRNA ligase
Identifiers
EC no.	6.1.1.15
CAS no.	9055-68-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are ATP, L-proline, and tRNA(Pro), whereas its 3 products are AMP, diphosphate, and L-prolyl-tRNA(Pro).

This enzyme participates in arginine and proline metabolism and aminoacyl-trna biosynthesis.

Nomenclature

This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-proline:tRNAPro ligase (AMP-forming). Other names in common use include prolyl-tRNA synthetase, prolyl-transferRNA synthetase, prolyl-transfer ribonucleate synthetase, proline translase, prolyl-transfer ribonucleic acid synthetase, prolyl-s-RNA synthetase, and prolinyl-tRNA ligase.