Pyridoxal 4-dehydrogenase

In enzymology, a pyridoxal 4-dehydrogenase (EC 1.1.1.107) is an enzyme that catalyzes the chemical reaction

pyridoxal + NAD⁺ ${\displaystyle \rightleftharpoons }$ 4-pyridoxolactone + NADH + H⁺

pyridoxal 4-dehydrogenase
Identifiers
EC no.	1.1.1.107
CAS no.	37250-39-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are pyridoxal and NAD⁺, whereas its 3 products are 4-pyridoxolactone, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is pyridoxal:NAD⁺ 4-oxidoreductase. This enzyme is also called pyridoxal dehydrogenase. This enzyme participates in vitamin B₆ metabolism.