Pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)

Pyridoxal 5′-phosphate synthase (glutamine hydrolysing) (EC 4.3.3.6, PdxST) is an enzyme with systematic name D-ribose 5-phosphate,D-glyceraldehyde 3-phosphate pyridoxal 5′-phosphate-lyase.^{[1][2][3][4][5][6][7][8]} This enzyme catalyses the following chemical reaction

D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine ${\displaystyle \rightleftharpoons }$ pyridoxal 5′-phosphate + L-glutamate + 3 H₂O + phosphate (overall reaction)

(1a) L-glutamine + H₂O ${\displaystyle \rightleftharpoons }$ L-glutamate + NH₃

(1b) D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH₃ ${\displaystyle \rightleftharpoons }$ pyridoxal 5′-phosphate + 4 H₂O + phosphate

PLP biosynthesis

Pyridoxal 5′-phosphate synthase (glutamine hydrolyzing)
Identifiers
EC no.	4.3.3.6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

The enzyme can also use ribulose 5-phosphate and dihydroxyacetone phosphate.