Pyridoxamine-phosphate transaminase

In enzymology, a pyridoxamine-phosphate transaminase (EC 2.6.1.54) is an enzyme that catalyzes the chemical reaction

pyridoxamine 5'-phosphate + 2-oxoglutarate ${\displaystyle \rightleftharpoons }$ pyridoxal 5'-phosphate + D-glutamate

pyridoxamine-phosphate transaminase
Identifiers
EC no.	2.6.1.54
CAS no.	9074-84-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are pyridoxamine 5'-phosphate and 2-oxoglutarate, whereas its two products are pyridoxal 5'-phosphate and D-glutamate.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is pyridoxamine-5'-phosphate:2-oxoglutarate aminotransferase (D-glutamate-forming). Other names in common use include pyridoxamine phosphate aminotransferase, pyridoxamine 5'-phosphate-alpha-ketoglutarate transaminase, and pyridoxamine 5'-phosphate transaminase. This enzyme participates in vitamin B₆ metabolism.