Pyridoxine 4-dehydrogenase

In enzymology, a pyridoxine 4-dehydrogenase (EC 1.1.1.65) is an enzyme that catalyzes the chemical reaction

pyridoxine + NADP⁺ ${\displaystyle \rightleftharpoons }$ pyridoxal + NADPH + H⁺

pyridoxine 4-dehydrogenase
Identifiers
EC no.	1.1.1.65
CAS no.	9028-64-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are pyridoxine and NADP⁺, whereas its 3 products are pyridoxal, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donors with NAD⁺ or NADP⁺ as acceptors. The systematic name of this enzyme class is pyridoxine:NADP⁺ 4-oxidoreductase. Other names in common use include pyridoxin dehydrogenase, pyridoxol dehydrogenase, and pyridoxine dehydrogenase. This enzyme participates in vitamin B₆ metabolism.