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Pyrimidine-nucleoside phosphorylase
Class of enzymes From Wikipedia, the free encyclopedia
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In enzymology, a pyrimidine-nucleoside phosphorylase (EC 2.4.2.2) is an enzyme that catalyzes the chemical reaction
- a pyrimidine nucleoside + phosphate a pyrimidine base + alpha-D-ribose 1-phosphate
Thus, the two substrates of this enzyme are pyrimidine nucleoside and phosphate, whereas its two products are pyrimidine base and alpha-D-ribose 1-phosphate.
This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is pyrimidine-nucleoside:phosphate alpha-D-ribosyltransferase. This enzyme is also called Py-NPase. This enzyme participates in pyrimidine metabolism.
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Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1BRW and 2DSJ.
References
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