Pyrimidodiazepine synthase

In enzymology, a pyrimidodiazepine synthase (EC 1.5.4.1) is an enzyme that catalyzes the chemical reaction

a pyrimidodiazepine + glutathione disulfide + H₂O ${\displaystyle \rightleftharpoons }$ 6-pyruvoyltetrahydropterin + 2 glutathione

pyrimidodiazepine synthase
Identifiers
EC no.	1.5.4.1
CAS no.	93586-06-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are pyrimidodiazepine, glutathione disulfide, and H₂O, whereas its two products are 6-pyruvoyltetrahydropterin and glutathione.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with a disulfide as acceptor. The systematic name of this enzyme class is pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing). Other names in common use include PDA synthase, pyrimidodiazepine:oxidized-glutathione oxidoreductase (ring-opening,, and cyclizing). This enzyme participates in glutathione metabolism.