Pyruvate oxidase (CoA-acetylating)

In enzymology, a pyruvate oxidase (CoA-acetylating) (EC 1.2.3.6) is an enzyme that catalyzes the chemical reaction

pyruvate + CoA + O₂ ${\displaystyle \rightleftharpoons }$ acetyl-CoA + CO₂ + H₂O₂

pyruvate oxidase (CoA-acetylating)
Identifiers
EC no.	1.2.3.6
CAS no.	62213-57-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are pyruvate, CoA, and O₂, whereas its 3 products are acetyl-CoA, CO₂, and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with oxygen as acceptor. The systematic name of this enzyme class is pyruvate:oxygen 2 - oxidoreductase (CoA-acetylating). This enzyme participates in pyruvate metabolism. It employs one cofactor, FAD.