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Pyrvinium
Chemical compound From Wikipedia, the free encyclopedia
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Pyrvinium (Viprynium) is an anthelmintic effective for pinworms.[1] Several forms of pyrvinium have been prepared with variable counter anions, such as halides, tosylate, triflate and pamoate.[2][3] Pyrvinium was identified as a potent Wnt inhibitor, acting through activation of Casein kinase CK1α.[4][5]
Pyrvinium salts can also inhibit the growth of cancer cells.[6] More specifically, the pamoate salt has been shown to have preferential toxicity for various cancer cell lines during glucose starvation.[7]
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Synthesis
One synthetic method is based on Skraup synthesis and Paal-Knorr synthesis.[6] More recently, an alternative convergent, synthetic strategy to pyrvinium triflate salts through Friedländer synthesis was reported.[3]
References
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