RECQL5

ATP-dependent DNA helicase Q5 is an enzyme that in humans is encoded by the RECQL5 gene.^[5][6]

RECQL5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4BK0, 5LB8, 5LB5, 5LBA, 5LB3
Identifiers
Aliases	RECQL5, RECQ5, RecQ like helicase 5
External IDs	OMIM: 603781; MGI: 2156841; HomoloGene: 31232; GeneCards: RECQL5; OMA:RECQL5 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.1 Start 75,626,845 bp[1] End 75,667,189 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 115,783,421 bp[2] End 115,824,303 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland right uterine tube left lobe of thyroid gland left testis anterior pituitary right testis sural nerve skin of abdomen body of stomach skin of leg Top expressed in granulocyte zygote spermatid neural layer of retina secondary oocyte lip tail of embryo corneal stroma ventricular zone plantaris muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II complex binding nucleotide binding helicase activity DNA helicase activity nucleic acid binding hydrolase activity ATP binding DNA binding 3'-5' DNA helicase activity four-way junction helicase activity protein binding identical protein binding Cellular component RNA polymerase II, holoenzyme nucleoplasm nucleus chromosome cytoplasm cytosol Biological process DNA recombination DNA metabolic process negative regulation of transcription elongation from RNA polymerase II promoter cellular response to DNA damage stimulus cell division chromosome separation DNA replication cell cycle DNA repair DNA duplex unwinding double-strand break repair via homologous recombination cellular response to camptothecin replication-born double-strand break repair via sister chromatid exchange negative regulation of double-strand break repair via homologous recombination mitotic cell cycle mitotic sister chromatid segregation response to X-ray negative regulation of mitotic cell cycle DNA unwinding involved in DNA replication metabolism Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9400 170472 Ensembl ENSG00000108469 ENSMUSG00000020752 UniProt O94762 Q8VID5 RefSeq (mRNA) NM_001003715 NM_001003716 NM_004259 NM_130454 RefSeq (protein) NP_001003715 NP_001003716 NP_004250 NP_569721 Location (UCSC) Chr 17: 75.63 – 75.67 Mb Chr 11: 115.78 – 115.82 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

RECQL5 has been shown to interact with EEF1G.^[7]