RAF kinase

RAF kinases are a family of three serine/threonine-specific protein kinases that are related to retroviral oncogenes.^[11] The mouse sarcoma virus 3611 contains a RAF kinase-related oncogene that enhances fibrosarcoma induction. RAF is an acronym for Rapidly Accelerated Fibrosarcoma.^[12]

The mitogen-activated protein kinase (MAPK) pathway.^{[1][2][3][4][5][6][7][8][9][10]} RAF-1 is between RAS and MEK just above the centre of the diagram.

RAF kinases participate in the RAS-RAF-MEK-ERK signal transduction cascade, also referred to as the mitogen-activated protein kinase (MAPK) cascade.^[11] Activation of RAF kinases requires interaction with RAS-GTPases.

The three RAF kinase family members are:

• A-RAF
• B-RAF
• c-Raf