Trihydroxystilbene synthase

In enzymology, a trihydroxystilbene synthase (EC 2.3.1.95) is an enzyme that catalyzes the chemical reaction

3 malonyl-CoA + 4-coumaroyl-CoA ${\displaystyle \rightleftharpoons }$ 4 CoA + 3,4',5-trihydroxy-stilbene + 4 CO₂

trihydroxystilbene synthase
Identifiers
EC no.	2.3.1.95
CAS no.	128449-70-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are malonyl-CoA and 4-coumaroyl-CoA, whereas its 3 products are CoA, 3,4',5-trihydroxy-stilbene (resveratrol), and CO₂.

This enzyme belongs to the family of transferases, To be specific those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing). Other names in common use include resveratrol synthase, and stilbene synthase.^[1] This enzyme participates in phenylpropanoid biosynthesis.^[1][2]

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1Z1E^[3] and 1Z1F.^[3]