Ribose 1-dehydrogenase (NADP+)

In enzymology, a ribose 1-dehydrogenase (NADP⁺) (EC 1.1.1.115) is an enzyme that catalyzes the chemical reaction

D-ribose + NADP⁺ + H₂O ${\displaystyle \rightleftharpoons }$ D-ribonate + NADPH + H⁺

ribose 1-dehydrogenase (NADP+)
Identifiers
EC no.	1.1.1.115
CAS no.	37250-46-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The three substrates of this enzyme are D-ribose, NADP⁺, and H₂O, whereas its 3 products are D-ribonate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is D-ribose:NADP⁺ 1-oxidoreductase. Other names in common use include D-ribose dehydrogenase (NADP⁺), NADP⁺-pentose-dehydrogenase, and ribose 1-dehydrogenase (NADP⁺).