Ribosyldihydronicotinamide dehydrogenase (quinone)

In enzymology, a ribosyldihydronicotinamide dehydrogenase (quinone) (EC 1.10.99.2) is an enzyme that catalyzes the chemical reaction

1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone ${\displaystyle \rightleftharpoons }$ 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone

dihydronicotinamide riboside quinone reductase
Ribosyldihydronicotinamide dehydrogenase dimer, Human
Identifiers
EC no.	1.10.99.2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide and quinone, whereas its two products are 1-(beta-D-ribofuranosyl)nicotinamide and hydroquinone.

This enzyme belongs to the family of oxidoreductases, specifically those acting on diphenols and related substances as donor with other acceptors. The systematic name of this enzyme class is 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide:quinone oxidoreductase. Other names in common use include NRH:quinone oxidoreductase 2, NQO2, NQO2, NAD(P)H:quinone oxidoreductase-2 (misleading), QR2, quinone reductase 2, N-ribosyldihydronicotinamide dehydrogenase (quinone), and NAD(P)H:quinone oxidoreductase2 (misleading).