Ro5-4864

Ro5-4864^[1] (4'-chlorodiazepam) is a drug which is a benzodiazepine derivative of diazepam.^[2] However unlike most benzodiazepine derivatives, Ro5-4864 lacks affinity for GABA_A receptors and lacks typical benzodiazepine effects,^[3] instead being sedative yet also convulsant and anxiogenic in effects.^[4][5][6][7] Ro5-4864 was found to be a potent ligand for the "peripheral benzodiazepine receptor",^[8] later renamed to mitochondrial translocator protein 18kDa (TSPO). Despite its convulsant effects, at lower doses Ro5-4864 has proved to be neuroprotective and has become widely used for research into the role of the TSPO protein in neurotoxicity.^{[9][10][11][12][13][14]} In vitro studies and rodent models also suggest the possibility of analgesic,^[15] antidepressant,^[16] cardioprotective,^[17] and anti-cancer effects.^{[18][19][20][21][non-primary source needed]}

Ro5-4864

Legal status
Legal status	CA: Schedule IV DE: NpSG (Industrial and scientific use only) UK: Under Psychoactive Substances Act US: Not FDA approved
Identifiers
IUPAC name 7-Chloro-5-(4-chlorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one
CAS Number	14439-61-3 Y
PubChem CID	1688
ChemSpider	1625 N
UNII	2QW0IK1742
CompTox Dashboard (EPA)	DTXSID3041116
ECHA InfoCard	100.162.290
Chemical and physical data
Formula	C16H12Cl2N2O
Molar mass	319.19 g·mol−1
3D model (JSmol)	Interactive image
SMILES Clc3ccc(cc3)C(=NCC1=O)c2cc(Cl)ccc2N1C
InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 N Key:PUMYFTJOWAJIKF-UHFFFAOYSA-N N
NY (what is this?)  (verify)

See also

• 4'-Chlorodeschloroalprazolam
• Diclazepam (2'-chlorodiazepam)
• PK-11195