Rosmarinate synthase

In enzymology, a rosmarinate synthase (EC 2.3.1.140) is an enzyme that catalyzes the chemical reaction

caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)lactate ${\displaystyle \rightleftharpoons }$ CoA + rosmarinate

rosmarinate synthase
Identifiers
EC no.	2.3.1.140
CAS no.	117590-80-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are caffeoyl-CoA and 3-(3,4-dihydroxyphenyl)lactate, whereas its two products are CoA and rosmarinate.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is caffeoyl-CoA:3-(3,4-dihydroxyphenyl)lactate 2'-O-caffeoyl-transferase. Other names in common use include rosmarinic acid synthase, caffeoyl-coenzyme A:3,4-dihydroxyphenyllactic acid, caffeoyltransferase, and 4-coumaroyl-CoA:4-hydroxyphenyllactic acid 4-coumaroyl transferase. This enzyme participates in tyrosine metabolism.