Rubredoxin—NAD(+) reductase

In enzymology, a rubredoxin-NAD⁺ reductase (EC 1.18.1.1) is an enzyme that catalyzes the chemical reaction.

2 reduced rubredoxin + NAD⁺ + H⁺ ${\displaystyle \rightleftharpoons }$ 2 oxidized rubredoxin + NADH

rubredoxin-NAD+ reductase
Identifiers
EC no.	1.18.1.1
CAS no.	9032-27-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are reduced rubredoxin, NAD⁺, and H⁺, whereas its two products are oxidized rubredoxin and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on iron-sulfur proteins as donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is rubredoxin:NAD⁺ oxidoreductase. Other names in common use include rubredoxin reductase, rubredoxin-nicotinamide adenine dinucleotide reductase, dihydronicotinamide adenine dinucleotide-rubredoxin reductase, reduced nicotinamide adenine dinucleotide-rubredoxin reductase, NADH-rubredoxin reductase, rubredoxin-NAD reductase, NADH: rubredoxin oxidoreductase, DPNH-rubredoxin reductase, and NADH-rubredoxin oxidoreductase. This enzyme participates in fatty acid metabolism. It has 2 cofactors: FAD and Iron.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1BFY.

See also

• Rubredoxin—NAD(P)(+) reductase