S-(hydroxymethyl)glutathione synthase

The enzyme S-(hydroxymethyl)glutathione synthase (EC 4.4.1.22) catalyzes the reaction

S-(hydroxymethyl)glutathione ${\displaystyle \rightleftharpoons }$ glutathione + formaldehyde

S-(hydroxymethyl)glutathione synthase
Identifiers
EC no.	4.4.1.22
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is S-(hydroxymethyl)glutathione formaldehyde-lyase (glutathione-forming). Other names in common use include glutathione-dependent formaldehyde-activating enzyme, Gfa, and S-(hydroxymethyl)glutathione formaldehyde-lyase. This enzyme participates in methane metabolism.