SB-206553

SB-206553 is a drug which acts as a mixed antagonist for the 5-HT_2B and 5-HT_2C serotonin receptors.^[1][2][3]

SB-206553

Identifiers
IUPAC name 5-methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrrolo[2,3-f]indole
CAS Number	158942-04-2
PubChem CID	5163
IUPHAR/BPS	189
ChemSpider	4979
UNII	AL4387525T
CompTox Dashboard (EPA)	DTXSID9043984
Chemical and physical data
Formula	C17H16N4O
Molar mass	292.342 g·mol−1
3D model (JSmol)	Interactive image
SMILES Cn2ccc(c2c3)cc1c3CCN1C(=O)Nc4cccnc4
InChI InChI=1S/C17H16N4O/c1-20-7-4-12-10-16-13(9-15(12)20)5-8-21(16)17(22)19-14-3-2-6-18-11-14/h2-4,6-7,9-11H,5,8H2,1H3,(H,19,22) Key:QJQORSLQNXDVGE-UHFFFAOYSA-N

Usage

It has anxiolytic properties in animal studies and interacts with a range of other drugs.^{[4][5][6][7][8][9][10][11][12]} It has also been shown to act as a positive allosteric modulator of α₇ nicotinic acetylcholine receptors.^[13] Modified derivatives of SB-206553 have been used to probe the structure of the 5-HT_2B receptor.^[14]

Development

SB-206553 was under development by GlaxoSmithKline for the treatment of anxiety disorders in the 1990s.^[15] However, its development was discontinued in 1996.^[15]