SCG2

SCG2, also called secretogranin II (chromogranin C), is a protein which in humans is encoded by the SCG2 gene.^[5]

SCG2
Identifiers
Aliases	SCG2, CHGC, SN, SgII, secretogranin II
External IDs	OMIM: 118930; MGI: 103033; HomoloGene: 2591; GeneCards: SCG2; OMA:SCG2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q36.1 Start 223,596,940 bp[1] End 223,602,361 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C4|1 40.89 cM Start 79,412,386 bp[2] End 79,417,837 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in beta cell lateral nuclear group of thalamus superior vestibular nucleus pituitary gland hypothalamus nucleus accumbens pars compacta middle temporal gyrus anterior pituitary pars reticulata Top expressed in islet of Langerhans dorsomedial hypothalamic nucleus ventral tegmental area arcuate nucleus ventromedial nucleus mammillary body paraventricular nucleus of hypothalamus dorsal tegmental nucleus median eminence adrenal gland More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding chemoattractant activity cytokine activity Cellular component extracellular region dense core granule secretory granule extracellular space neuronal dense core vesicle endoplasmic reticulum lumen Biological process protein secretion induction of positive chemotaxis negative regulation of endothelial cell apoptotic process eosinophil chemotaxis positive chemotaxis negative regulation of extrinsic apoptotic signaling pathway intracellular signal transduction inflammatory response positive regulation of endothelial cell proliferation endothelial cell migration angiogenesis MAPK cascade negative regulation of endothelial cell proliferation post-translational protein modification regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7857 20254 Ensembl ENSG00000171951 ENSMUSG00000050711 UniProt P13521 P15321 Q03517 RefSeq (mRNA) NM_003469 NM_009129 NM_001310680 RefSeq (protein) NP_003460 NP_001297609 NP_033155 Location (UCSC) Chr 2: 223.6 – 223.6 Mb Chr 1: 79.41 – 79.42 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotactic effects on specific cell types, and EM66, whose function is unknown.^[6]

See also

• Chromogranin

Further reading

• Kirchmair R, Gander R, Egger M, et al. (2004). "The neuropeptide secretoneurin acts as a direct angiogenic cytokine in vitro and in vivo". Circulation. 109 (6): 777–83. doi:10.1161/01.CIR.0000112574.07422.C1. PMID 14970115.
• Ozawa H, Takata K (1995). "The granin family--its role in sorting and secretory granule formation". Cell Struct. Funct. 20 (6): 415–20. doi:10.1247/csf.20.415. PMID 8825061.
• Huttner WB, Gerdes HH, Rosa P (1991). "The granin (chromogranin/secretogranin) family". Trends Biochem. Sci. 16 (1): 27–30. doi:10.1016/0968-0004(91)90012-K. PMID 2053134.
• Stemberger K, Pallhuber J, Doblinger A, et al. (2004). "Secretoneurin in the human aqueous humor and the absence of an effect of frequently used eye drops on the levels". Peptides. 25 (12): 2115–8. doi:10.1016/j.peptides.2004.08.010. PMID 15572199. S2CID 21826451.
• Scammell JG, Reddy S, Valentine DL, et al. (2000). "Isolation and characterization of the human secretogranin II gene promoter". Brain Res. Mol. Brain Res. 75 (1): 8–15. doi:10.1016/S0169-328X(99)00269-7. PMID 10648883.
• Kähler CM, Schratzberger P, Kaufmann G, et al. (2002). "Transendothelial migration of leukocytes and signalling mechanisms in response to the neuropeptide secretoneurin". Regul. Pept. 105 (1): 35–46. doi:10.1016/S0167-0115(01)00379-2. PMID 11853870. S2CID 6144086.
• Beranova-Giorgianni S, Zhao Y, Desiderio DM, Giorgianni F (2006). "Phosphoproteomic analysis of the human pituitary". Pituitary. 9 (2): 109–20. doi:10.1007/s11102-006-8916-x. PMID 16807684. S2CID 10789246.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
• Kato A, Kammen-Jolly K, Fischer-Colbie R, et al. (2000). "Co-distribution patterns of chromogranin B-like immunoreactivity with chromogranin A and secretoneurin within the human brainstem". Brain Res. 852 (2): 444–52. doi:10.1016/S0006-8993(99)02229-5. PMID 10678772. S2CID 22936622.
• Schrott-Fischer A, Bitsche M, Humpel C, et al. (2009). "Chromogranin peptides in amyotrophic lateral sclerosis". Regul. Pept. 152 (1–3): 13–21. doi:10.1016/j.regpep.2008.07.009. PMID 18721831. S2CID 207494362.
• Fischer-Colbrie R, Kirchmair R, Kähler CM, et al. (2005). "Secretoneurin: a new player in angiogenesis and chemotaxis linking nerves, blood vessels and the immune system". Curr. Protein Pept. Sci. 6 (4): 373–85. doi:10.2174/1389203054546334. PMID 16101435.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
• Lankat-Buttgereit B, Müller S, Schmidt H, et al. (2008). "Knockdown of Pdcd4 results in induction of proprotein convertase 1/3 and potent secretion of chromogranin A and secretogranin II in a neuroendocrine cell line". Biol. Cell. 100 (12): 703–15. doi:10.1042/BC20080052. PMID 18549351. S2CID 8007910.
• Stridsberg M, Eriksson B, Janson ET (2008). "Measurements of secretogranins II, III, V and proconvertases 1/3 and 2 in plasma from patients with neuroendocrine tumours". Regul. Pept. 148 (1–3): 95–8. doi:10.1016/j.regpep.2008.03.007. PMID 18448176. S2CID 24853860.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wen G, Wessel J, Zhou W, et al. (2007). "An ancestral variant of Secretogranin II confers regulation by PHOX2 transcription factors and association with hypertension". Hum. Mol. Genet. 16 (14): 1752–64. doi:10.1093/hmg/ddm123. PMC 2695823. PMID 17584765.
• Yon L, Guillemot J, Montero-Hadjadje M, et al. (2003). "Identification of the secretogranin II-derived peptide EM66 in pheochromocytomas as a potential marker for discriminating benign versus malignant tumors". J. Clin. Endocrinol. Metab. 88 (6): 2579–85. doi:10.1210/jc.2002-021748. PMID 12788858.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wu C, Ma MH, Brown KR, et al. (2007). "Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening". Proteomics. 7 (11): 1775–85. doi:10.1002/pmic.200601006. PMID 17474147. S2CID 22474278.
• Li L, Hung AC, Porter AG (2008). "Secretogranin II: a key AP-1-regulated protein that mediates neuronal differentiation and protection from nitric oxide-induced apoptosis of neuroblastoma cells". Cell Death Differ. 15 (5): 879–88. doi:10.1038/cdd.2008.8. PMID 18239671. S2CID 205116721.