GLUT2

Glucose transporter 2 (GLUT2) also known as solute carrier family 2 (facilitated glucose transporter), member 2 (SLC2A2) is a transmembrane carrier protein that enables protein facilitated glucose movement across cell membranes. It is the principal transporter for transfer of glucose between liver and blood^[5] Unlike GLUT4, it does not rely on insulin for facilitated diffusion.

SLC2A2
Identifiers
Aliases	SLC2A2, GLUT2, solute carrier family 2 member 2
External IDs	OMIM: 138160; MGI: 1095438; HomoloGene: 68047; GeneCards: SLC2A2; OMA:SLC2A2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q26.2 Start 170,996,347 bp[1] End 171,026,743 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 A3|3 12.19 cM Start 28,752,052 bp[2] End 28,785,508 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver jejunal mucosa duodenum mucosa of ileum kidney tubule testicle islet of Langerhans human kidney glomerulus metanephric glomerulus Top expressed in islet of Langerhans left lobe of liver yolk sac human kidney right kidney duodenum gallbladder jejunum primitive streak epithelium of small intestine More reference expression data BioGPS n/a
Gene ontology Molecular function transporter activity transmembrane transporter activity hexose transmembrane transporter activity dehydroascorbic acid transmembrane transporter activity glucose transmembrane transporter activity D-glucose transmembrane transporter activity Cellular component brush border cytoplasm integral component of membrane cell-cell junction integral component of plasma membrane apical plasma membrane membrane plasma membrane Biological process hexose transmembrane transport dehydroascorbic acid transport carbohydrate transport regulation of insulin secretion transmembrane transport intestinal hexose absorption carbohydrate metabolic process glucose transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6514 20526 Ensembl ENSG00000163581 ENSMUSG00000027690 UniProt P11168 P14246 RefSeq (mRNA) NM_000340 NM_001278658 NM_001278659 NM_031197 RefSeq (protein) NP_000331 NP_001265587 NP_001265588 NP_112474 Location (UCSC) Chr 3: 171 – 171.03 Mb Chr 3: 28.75 – 28.79 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Glut2basal.png

In humans, this protein is encoded by the SLC2A2 gene.^[6][7]

Tissue distribution

GLUT2 is found in cellular membranes of:

• liver (Primary)
• pancreatic β cell (Primary in mice, tertiary in humans after GLUT1 and GLUT3)^[8]
• hypothalamus (Not overly significant)
• basolateral membrane of small intestine and apical GLUT2 is also suggested.^[9]
• basolateral membrane of renal tubular cells^[10][11]

Function

GLUT2 has high capacity for glucose but low affinity (high K_M, ca. 15–20 mM) and thus functions as part of the "glucose sensor" in the pancreatic β-cells of rodents, though in human β-cells the role of GLUT2 seems to be a minor one.^[8] It is a very efficient carrier for glucose.^[12][13] Similarly, a recent study showed that lack of GLUT2 in β-cells doesn't impair glucose homeostasis or glucose-stimulated insulin secretion in mice.^[14]

GLUT2 also carries glucosamine.^[15]

When the glucose concentration in the lumen of the small intestine goes above 30 mM, such as occurs in the fed-state, GLUT2 is up-regulated at the brush border membrane, enhancing the capacity of glucose transport. Basolateral GLUT2 in enterocytes also aids in the transport of fructose into the bloodstream through glucose-dependent cotransport. Recent studies show that renal GLUT2 contributes to systemic glucose homeostasis by regulating glucose reabsorption.^[11] Lack of renal Glut2 reversed features of diabetes and obesity in mice. In addition, renal Glut2 deficiency caused knockdown of renal Sglt2 through the transcription factor Hnf1α.^[11]

Clinical significance

Defects in the SLC2A2 gene are associated with a particular type of glycogen storage disease called Fanconi-Bickel syndrome.^[16]

In drug-treated diabetic pregnancies in which glucose levels in the woman are uncontrolled, neural tube and cardiac defects in the early-developing brain, spine, and heart depend upon functional GLUT2 carriers, and defects in the GLUT2 gene have been shown to be protective against such defects in rats.^[17] However, whilst a lack of GLUT2 adaptability^[18] is negative, it is important to remember the fact that the main result of untreated gestational diabetes appears to cause babies to be of above-average size, which may well be an advantage that is managed very well with a healthy GLUT2 status.

Maintaining a regulated osmotic balance of sugar concentration between the blood circulation and the interstitial spaces is critical in some cases of edema including cerebral edema.

GLUT2 appears to be particularly important to osmoregulation, and preventing edema-induced stroke, transient ischemic attack or coma, especially when blood glucose concentration is above average.^[19] GLUT2 could reasonably be referred to as the "diabetic glucose transporter" or a "stress hyperglycemia glucose transporter."

SLC2A2 was associated with clinical stages and independently associated with overall survival in patients with Hepatocellular carcinoma, and could be considered a new prognostic factor for HCC.^[20]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Glycolysis and Gluconeogenesis edit]]

Glycolysis and Gluconeogenesis edit

1. The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

See also

• Glucose transporter