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SMIM11
From Wikipedia, the free encyclopedia
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Small integral membrane protein 11 is a protein which in humans is encoded by the SMIM11 gene.[3][4]
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Gene
Locus
SMIM11 is located on the plus strand of chromosome 21 and has 4 exons.[4]
Expression
The expression of SMIM11 is highest in the brain, thyroid, and stomach, though it is also expressed in many other tissues.[4]
mRNA
There are no known transcript variants or isoforms of SMIM11.[5]
Protein
The SMIM11 protein is 58 amino acids long. The theoretical molecular weight of this protein is 6kDa and the theoretical pI is 9.[6] The protein is localized in the cytoplasm and mitochondria, as well as focal adhesion points between the cells.[7][8]
Domains, Motifs, and Post-translational Modifications
SMIM11 contains a transmembrane domain.[9] The protein also holds a dileucine motif. Post-translational modifications include ubiquitylation site, as well as two phosphorylated sites, one on a threonine and one on a serine[10][11]
Secondary Structure and Tertiary Structure
The protein is composed mostly of alpha-helices.[12] The N-terminus of SMIM11 sticks out into the extracellular matrix, while the C-terminal end is located within the cytoplasm of the cell.[13]
Quaternary Structure and Protein Interactions
Experimentally-determined protein interactions for SMIM11 have not yet been identified.[14]
Homology and Evolution
Paralogs
No paralogs or paralogous domains exist for SMIM11
Orthologs
SMIM11 has a large number of orthologs. These orthologs range from other mammals to birds, reptiles, amphibians, and bony fish.[15]
References
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