HT-2157

HT-2157 (former development code SNAP-37889) is a drug which acts as a selective non-peptide antagonist for the receptor GAL-3, which is usually activated by the neuropeptide galanin. Blocking this receptor with HT-2157 produced increased serotonin release,^[1] as well as producing antidepressant and anxiolytic effects in animal studies,^[2] and it was also being researched for treatment of cognitive dysfunction.^[3] All human clinical trials were terminated due to safety concerns however, and new GAL-3 antagonists are now being sought instead.^[4]

HT-2157

Clinical data
ATC code	none
Identifiers
IUPAC name 1-Phenyl-3-[3-(trifluoromethyl)phenyl]iminoindol-2-one
CAS Number	303149-14-6
PubChem CID	1471834
IUPHAR/BPS	6126
ChemSpider	1213983
UNII	J4DRJ9BFS1
Chemical and physical data
Formula	C21H13F3N2O
Molar mass	366.343 g·mol−1
3D model (JSmol)	Interactive image
SMILES c14ccccc4n(-c3ccccc3)c(=O)c1=N\c(c2)cccc2C(F)(F)F
InChI InChI=1S/C21H13F3N2O/c22-21(23,24)14-7-6-8-15(13-14)25-19-17-11-4-5-12-18(17)26(20(19)27)16-9-2-1-3-10-16/h1-13H/b25-19+ Key:TXCGMRVPXUBHAL-NCELDCMTSA-N