STAP1

Signal-transducing adaptor protein 1 is a protein that in humans is encoded by the STAP1 gene.^[5][6][7]

STAP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X1F, 3MAZ
Identifiers
Aliases	STAP1, BRDG1, STAP-1, signal transducing adaptor family member 1
External IDs	OMIM: 604298; MGI: 1926193; HomoloGene: 8103; GeneCards: STAP1; OMA:STAP1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q13.2 Start 67,558,727 bp[1] End 67,607,337 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E1 Start 86,219,605 bp[2] End 86,253,984 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lymph node epithelium of nasopharynx spleen appendix granulocyte bone marrow cells testicle tonsil superficial temporal artery blood Top expressed in granulocyte thymus spleen mesenteric lymph nodes olfactory epithelium blood lumbar spinal ganglion subcutaneous adipose tissue tibiofemoral joint lumbar subsegment of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function macrophage colony-stimulating factor receptor binding transmembrane receptor protein tyrosine kinase adaptor activity phosphotyrosine residue binding receptor tyrosine kinase binding protein binding phospholipid binding protein kinase binding signaling adaptor activity Cellular component cytoplasm mitochondrion nucleus nucleoplasm intracellular membrane-bounded organelle protein-containing complex Biological process positive regulation of B cell receptor signaling pathway positive regulation of phagocytosis, engulfment transmembrane receptor protein tyrosine kinase signaling pathway negative regulation of ruffle assembly positive regulation of microglial cell mediated cytotoxicity positive regulation of non-membrane spanning protein tyrosine kinase activity negative regulation of microglial cell migration positive regulation of gene expression positive regulation of microglial cell activation negative regulation of phosphorylation cellular response to lipopolysaccharide negative regulation of macrophage colony-stimulating factor signaling pathway positive regulation of actin cytoskeleton reorganization negative regulation of macrophage chemotaxis response to bacterium Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26228 56792 Ensembl ENSG00000035720 ENSMUSG00000029254 UniProt Q9ULZ2 Q9JM90 RefSeq (mRNA) NM_012108 NM_001317769 NM_019992 NM_001310639 RefSeq (protein) NP_001304698 NP_036240 NP_001297568 NP_064376 Location (UCSC) Chr 4: 67.56 – 67.61 Mb Chr 5: 86.22 – 86.25 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is directly phosphorylated by Tec in vitro where it participates in a positive feedback loop, increasing Tec activity. A mouse ortholog, stem cell adaptor protein 1, shares 83% identity with its human counterpart.^[7]

Interactions

STAP1 has been shown to interact with C19orf2.^[8]