Small nucleolar RNA snR60/Z15/Z230/Z193/J17

In molecular biology, snoRNA snR60 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA snR60 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.^[1] snoRNA snR60 was initially discovered using a computational screen of the Saccharomyces cerevisiae genome,^[2] subsequent experimental screens discovered plant homologues Z15, Z230, Z193 and J17^[3] and human U80/SNORD80.

Small nucleolar RNA snR60/Z15/Z230/Z193/J17
Predicted secondary structure and sequence conservation of snosnR60_Z15
Identifiers
Symbol	snosnR60_Z15
Alt. Symbols	snoZ193
Rfam	RF00309
Other data
RNA type	Gene; snRNA; snoRNA; CD-box
Domain	Eukaryota
GO	GO:0006396 GO:0005730
SO	SO:0000593
PDB structures	PDBe