Sphingosine cholinephosphotransferase

In enzymology, a sphingosine cholinephosphotransferase (EC 2.7.8.10) is an enzyme that catalyzes the chemical reaction

CDP-choline + sphingosine ${\displaystyle \rightleftharpoons }$ CMP + sphingosyl-phosphocholine

sphingosine cholinephosphotransferase
Identifiers
EC no.	2.7.8.10
CAS no.	9027-12-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are CDP-choline and sphingosine, whereas its two products are CMP and sphingosyl-phosphocholine.

This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is CDP-choline:sphingosine cholinephosphotransferase. Other names in common use include CDP-choline-sphingosine cholinephosphotransferase, phosphorylcholine-sphingosine transferase, cytidine diphosphocholine-sphingosine cholinephosphotransferase, and sphingosine choline phosphotransferase. This enzyme participates in sphingolipid metabolism.