Spi-1 (PU.1) 5′ UTR regulatory element

The Spi-1 (PU.1) 5′ UTR regulatory element is an RNA element found in the 5′ UTR of Spi-1 mRNA which is able to inhibit the translation Spi-1 transcripts by 8-fold.^[1] Spi-1 regulates myeloid gene expression during haemopoietic development. Mutations in this regulatory region of the 5′ UTR can lead to overexpression of Spi-1 which has been linked to development of leukaemia.^[1]

Spi-1 (PU.1) 5′ UTR regulatory element
Predicted secondary structure and sequence conservation of Spi-1
Identifiers
Symbol	Spi-1
Rfam	RF00232
Other data
RNA type	Cis-reg
Domain(s)	Eukaryota
SO	SO:0000204
PDB structures	PDBe

See also

• InvR