Succinate—hydroxymethylglutarate CoA-transferase

In enzymology, a succinate-hydroxymethylglutarate CoA-transferase (EC 2.8.3.13) is an enzyme that catalyzes the chemical reaction

succinyl-CoA + 3-hydroxy-3-methylglutarate ${\displaystyle \rightleftharpoons }$ succinate + (S)-3-hydroxy-3-methylglutaryl-CoA

succinate-hydroxymethylglutarate CoA-transferase
Identifiers
EC no.	2.8.3.13
CAS no.	80237-90-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are succinyl-CoA and 3-hydroxy-3-methylglutarate, whereas its two products are succinate and (S)-3-hydroxy-3-methylglutaryl-CoA.

This enzyme belongs to the family of transferases, specifically the CoA-transferases. The systematic name of this enzyme class is succinyl-CoA:3-hydroxy-3-methylglutarate CoA-transferase. Other names in common use include hydroxymethylglutarate coenzyme A-transferase, and dicarboxyl-CoA:dicarboxylic acid coenzyme A transferase.