Succinyl-diaminopimelate desuccinylase

In enzymology, a succinyl-diaminopimelate desuccinylase (EC 3.5.1.18) is an enzyme that catalyzes the chemical reaction

N-succinyl-LL-2,6-diaminoheptanedioate + H₂O ${\displaystyle \rightleftharpoons }$ succinate + LL-2,6-diaminoheptanedioate

succinyl-diaminopimelate desuccinylase
Identifiers
EC no.	3.5.1.18
CAS no.	9024-94-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are N-succinyl-LL-2,6-diaminoheptanedioate and H₂O, whereas its two products are succinate and LL-2,6-diaminoheptanedioate.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase. This enzyme is also called N-succinyl-L-alpha,epsilon-diaminopimelic acid deacylase. This enzyme participates in lysine biosynthesis.