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Sulfapyridine
Chemical compound From Wikipedia, the free encyclopedia
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Sulfapyridine (INN; also known as sulphapyridine) is a sulfanilamide antibacterial medication. At one time, it was commonly referred to as M&B 693. Sulfapyridine is no longer prescribed for treatment of infections in humans. However, it may be used to treat linear IgA disease and has use in veterinary medicine.[1] It is a good antibacterial drug, but its water solubility is very pH dependent. Thus there is a risk of crystallization within the bladder or urethra, which could lead to pain or blockage. As with other sulfonamides, there is a significant risk of agranulocytosis, and this, rather than the development of resistance by bacteria, is the main reason for its decline in use.
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Sulfapyridine was one of the first generation of sulfonamide antibiotics. It was first synthesised by chemist Montague Phillips, working under director of research Arthur Ewins at the British firm May & Baker Ltd, Dagenham on 2 November 1937. This sample was recorded in their test log as T693.[2]
Animal testing was conducted by clinical pathologist Lionel Whitby at the Bland-Sutton Institute of Pathology, Middlesex Hospital in London under the designation M&B 693. Whitby discovered the antibacterial properties of sulfapyridine against pneumococci and a range of other bacteria in mice.[3]
Clinical trials were conducted between March and June 1938 at Dudley Road Hospital, Birmingham by doctors G. Mary Evans and Wilfrid Gaisford. These trials demonstrated a 70% reduction in mortality in 100 patients with lobar pneumonia.[4]
May & Baker began marketing sulphapyridine in the UK under the trade name Dagenan in October 1938.[5]
During the aftermath to the disastrous convoy SC7, in October 1940, Surgeon-Lieutenant John Robertson, RN, of HMS Leith, saved the life of Commodore Lachlan MacKinnon, from the torpedoed Assyrian, who had developed pneumonia, by giving him M&B 693, despite Robertson never having used it before and not knowing the required dosage.[6]
M&B 693 was successfully used to treat Winston Churchill's bacterial pneumonia.[7][8]
The same source records that in 1944 M&B 693 also saved Nero, the Royal Circus lion, from pneumonia.[9]
It could either be taken in tablet form or the powder could be placed in wounds. It was used so widely during the Second World War that May & Baker had difficulty keeping up with demand. It was later largely superseded by penicillin and other sulfonamides.
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Related medications
The drug sulfasalazine is structurally one molecule of mesalamine linked to one molecule of sulfapyridine with an azo chemical linker.
References
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