Angiopoietin receptor

The angiopoietin receptors are receptors that bind angiopoietin. TIE-1 and TIE-2 comprise the cell-surface receptors that bind and are activated by the angiopoietins, (Ang1, Ang2, Ang3, Ang4). The angiopoietins are protein growth factors required for the formation of blood vessels (angiogenesis).

Angiopoietin receptor
Identifiers
Symbol	TIE
Pfam	PF10430
InterPro	IPR018941
Membranome	1214
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Identifiers
Symbol	TIE1
Alt. symbols	TIE, JTK14
NCBI gene	7075
HGNC	11809
OMIM	600222
RefSeq	NM_005424
UniProt	P35590
Other data
EC number	2.7.1.112
Locus	Chr. 1 p34-p33
Search for Structures Swiss-model Domains InterPro

TEK tyrosine kinase, endothelial
Identifiers
Symbol	TEK
Alt. symbols	TIE2, TIE-2, VMCM1, CD202b
NCBI gene	7010
HGNC	11724
OMIM	600221
RefSeq	NM_000459
UniProt	Q02763
Other data
Locus	Chr. 9 p21
Search for Structures Swiss-model Domains InterPro

ANGPT1, ANGPT2, and ANGPT4 activate TIE-2. Intracellular signal transduction can proceed via DOK-R (yellow arrow) or alternatively via Akt to eNOS (orange arrow).

Angiopoietins

The angiopoietins are protein growth factors that regulate angiogenesis, the formation of blood vessels. In humans, three angiopoietins have been identified: Ang1, Ang2, and Ang4 (Ang 3 is the mouse ortholog of human Ang4).^[1] Ang1 and Ang4 function as agonistic or activating ligands for Tie2, whereas Ang2 and Ang3 behave as competitive antagonists. They function by binding their physiologic receptors, Tie-1 and Tie-2. These are receptor tyrosine kinases, so named because they mediate cell signals by inducing the phosphorylation of key tyrosines, thus initiating cell signalling.

It is somewhat controversial which of the Tie receptors mediate functional signals downstream of Ang stimulation. But it is clear that at least Tie-2 is capable of physiologic activation as a result of binding the angiopoietins.^{[citation needed]}

See also

• Angiopoietin § Tie pathway

External links

• TIE+Receptor+Tyrosine+Kinases at the U.S. National Library of Medicine Medical Subject Headings (MeSH)