TRNA (guanine37-N1)-methyltransferase

tRNA (guanine³⁷-N¹)-methyltransferase (EC 2.1.1.228, TrmD, tRNA (m1G37) methyltransferase, transfer RNA (m1G37) methyltransferase, Trm5p, TRMT5, tRNA-(N1G37) methyltransferase, MJ0883 (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine³⁷-N¹)-methyltransferase.^{[1][2][3][4][5][6]} This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + guanine³⁷ in tRNA ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + N¹-methylguanine³⁷ in tRNA

tRNA (guanine37-N1)-methyltransferase
Identifiers
EC no.	2.1.1.228
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

This enzyme is important for the maintenance of the correct reading frame during translation.