TRNA-pseudouridine synthase I

In enzymology, a tRNA-pseudouridine synthase I (EC 5.4.99.12) is an enzyme that catalyzes the chemical reaction

tRNA uridine ${\displaystyle \rightleftharpoons }$ tRNA pseudouridine

tRNA-pseudouridine synthase
Identifiers
EC no.	5.4.99.12
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Hence, this enzyme has one substrate, tRNA uridine, and one product, tRNA pseudouridine.

This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring other groups. The systematic name of this enzyme class is tRNA-uridine uracilmutase. Other names in common use include tRNA-uridine isomerase, tRNA pseudouridylate synthase I, transfer ribonucleate pseudouridine synthetase, pseudouridine synthase, and transfer RNA pseudouridine synthetase.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1VS3, 2NQP, 2NR0, and 2NRE.