TRNA dimethylallyltransferase

TRNA dimethylallyltransferase (EC 2.5.1.75, tRNA prenyltransferase, MiaA, transfer ribonucleate isopentenyltransferase, Delta2-isopentenyl pyrophosphate:tRNA-Delta2-isopentenyl transferase, Delta2-isopentenyl pyrophosphate:transfer ribonucleic acid Delta2-isopentenyltransferase) is an enzyme with systematic name dimethylallyl-diphosphate: tRNA dimethylallyltransferase.^[1][2][3] This enzyme catalyses the following chemical reaction

dimethylallyl diphosphate + tRNA ${\displaystyle \rightleftharpoons }$ diphosphate + tRNA containing 6-dimethylallyladenosine

TRNA dimethylallyltransferase
Identifiers
EC no.	2.5.1.75
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
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Formerly known as tRNA isopentenyltransferase (EC 2.5.1.8), but it is now known that dimethylallyl diphosphate, rather than isopentenyl diphosphate, is the substrate.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2QGN.