TRNA pseudouridine38/39 synthase

tRNA pseudouridine^38/39 synthase (EC 5.4.99.45, Deg1, Pus3p, pseudouridine synthase 3) is an enzyme with systematic name tRNA-uridine^38/39 uracil mutase.^[1][2] This enzyme catalyses the following chemical reaction

tRNA uridine^38/39 ${\displaystyle \rightleftharpoons }$ tRNA pseudouridine^38/39

tRNA pseudouridine38/39 synthase
Identifiers
EC no.	5.4.99.45
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

The enzyme from Saccharomyces cerevisiae is active only towards uridine³⁸ and uridine³⁹.

See also

• PUS1
• Mitochondrial tRNA pseudouridine27/28 synthase