TRPC4

The short transient receptor potential channel 4 (TrpC4), also known as Trp-related protein 4, is a protein that in humans is encoded by the TRPC4 gene.^[5][6]

TRPC4
Identifiers
Aliases	TRPC4, HTRP-4, HTRP4, TRP4, transient receptor potential cation channel subfamily C member 4
External IDs	OMIM: 603651; MGI: 109525; HomoloGene: 22955; GeneCards: TRPC4; OMA:TRPC4 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q13.3 Start 37,632,063 bp[1] End 37,869,802 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 C|3 25.43 cM Start 54,063,456 bp[2] End 54,225,892 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium decidua smooth muscle tissue testicle body of uterus right coronary artery myometrium left coronary artery prostate gallbladder Top expressed in lateral septal nucleus subiculum Region I of hippocampus proper CA3 field dentate gyrus anterior amygdaloid area hippocampus proper dentate gyrus of hippocampal formation granule cell barrel cortex secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function beta-catenin binding store-operated calcium channel activity cadherin binding inositol 1,4,5 trisphosphate binding ion channel activity protein binding calcium channel activity Cellular component integral component of membrane calcium channel complex membrane cell-cell junction cortical cytoskeleton plasma membrane cell surface basolateral plasma membrane caveola membrane raft integral component of plasma membrane protein-containing complex cation channel complex Biological process regulation of cytosolic calcium ion concentration calcium ion import oligodendrocyte differentiation ion transport calcium ion transmembrane transport manganese ion transport gamma-aminobutyric acid secretion calcium ion transport transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7223 22066 Ensembl ENSG00000133107 ENSMUSG00000027748 UniProt Q9UBN4 Q9QUQ5 RefSeq (mRNA) NM_001135955 NM_001135956 NM_001135957 NM_001135958 NM_003306 NM_016179 NM_001354799 NM_001354806 NM_001372055 NM_001253682 NM_001253683 NM_016984 RefSeq (protein) NP_001129427 NP_001129428 NP_001129429 NP_001129430 NP_003297 NP_057263 NP_001341728 NP_001341735 NP_001358984 NP_001240611 NP_001240612 NP_058680 Location (UCSC) Chr 13: 37.63 – 37.87 Mb Chr 3: 54.06 – 54.23 Mb PubMed search [3] [4]
Wikidata
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Function

TrpC4 is a member of the transient receptor potential cation channels. This protein forms a non-selective calcium-permeable cation channel that is activated by Gαi-coupled receptors, Gαq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation.^[7]

Tissue distribution

The nonselective cation channel TrpC4 has been shown to be present in high abundance in the cortico-limbic regions of the brain.^[8] In addition, TRPC4 mRNA is present in midbrain dopaminergic neurons in the ventral tegmental area and the substantia nigra.^[9]

Roles

Deletion of the trpc4 gene decreases levels of sociability in a social exploration task. These results suggest that TRPC4 may play a role in regulating social anxiety in a number of different disorders.^[10] However deletion of the trpc4 gene had no impact on basic or complex strategic learning.^[11] Given that the trpc4 gene is expressed in a select population of midbrain dopamine neurons, it has been proposed that it may have an important role in dopamine related processes including addiction and attention.^[9]

Clinical significance

Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity.^[12]

Interactions

TRPC4 has been shown to interact with ITPR1,^[13][14] TRPC1,^[15][16] and TRPC5.^[16]

See also

• TRPC