Drugs secreted in the kidney

This is a table of drugs that are secreted in the kidney.

Acid medication are, because of pH partition, secreted to a higher extent when urine is basic. In the same way, basic medications are secreted to a higher extent when urine is acidic.

Medication	Location	Acid or base[1]	anion or cation[2]	Percentage excreted[3]
para-aminohippurate	proximal tubule[4]	Acid	anion
furosemide	proximal tubule[4]	Acid	anion	100-75
glucuronic acid-conjugates	proximal tubule[4]	Acid
glycine conjugates	proximal tubule[4]	Acid
indometacin	proximal tubule[4]	Acid	anion
methotrexate	proximal tubule[4]	Acid		100-75
penicillin	proximal tubule[4]	Acid	anion	75-50 (benzylpenicillin)
probenecid	proximal tubule[4]	Acid	anion
sulphate conjugates	proximal tubule[4]	Acid
thiazide diuretics	proximal tubule[4]	Acid
uric acid	proximal tubule[4]	Acid
amiloride	proximal tubule[4]	Base	cation
dopamine	proximal tubule[4]	Base
histamine	proximal tubule[4]	Base
mepacrine	proximal tubule[4]	Base
morphine	proximal tubule[4]	Base	cation
pethidine	proximal tubule[4]	Base
quaternary ammonium compounds	proximal tubule[4]	Base
quinine	proximal tubule[4]	Base	cation
5-hydroxytryptamine (serotonin)	proximal tubule[4]	Base
triamterene	proximal tubule[4]	Base
gentamicin				100-75
atenolol				100-75
digoxin				100-75
cimetidine			cation	75-50
tetracycline				75-50 (oxytetracycline)
neostigmine				75-50
propantheline				~50
tubocurarine				~50
acetazolamide	proximal tubule[5]		anion
chlorothiazide	proximal tubule[5]		anion
saccharin	proximal tubule[5]		anion
salicylate	proximal tubule[5]		anion
atropine	proximal tubule[5]		cation
NMN	proximal tubule[5]		cation
paraquat	proximal tubule[5]		cation
procainamide	proximal tubule[5]		cation
tetraethylammonium	proximal tubule[5]		cation
chlorpromazine	proximal tubule[5]		cation