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Tangeretin

Chemical compound From Wikipedia, the free encyclopedia

Tangeretin
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Tangeretin is an O-polymethoxylated flavone that is found in tangerine and other citrus peels. Tangeretin strengthens the cell wall and acts as a plant's defensive mechanism against disease-causing pathogens.[2]

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It has also been used as a marker compound to detect contamination in citrus juices.[2]

The following is a list of methods used to extract tangeretin from citrus peels:

  • column chromatography
  • preparative-high performance liquid chromatography
  • super critical fluid chromatography
  • high speed counter current chromatography
  • a combination of vacuum flash silica gel chromatography and flash C8 column chromatography
  • flash chromatography
  • isolation using ionic liquids and a cycle of centrifugation and decantation[3]

The low solubility of Tangeretin is one of the main reasons for the low bioavailability of Tangeretin (and other flavonoids in general), and has been reported as a major challenge when using the compound in laboratory procedures.[4] However, methods for tangeretin extraction are currently being tested to maximize efficiency and percent yields as its uses in treatment of cancer and other diseases are becoming better understood.[2]

Tangeretin is commercially available as a dietary supplement. Tangeretin has also demonstrated beneficial applications in other pharmaceutical, nutraceutical, and cosmetic processes.[4]

Tangeretin can be found as various synonyms throughout literature and research, including Tangeritin and 5,6,7,8,4’-pentamethoxyflavone (VIII).[3]

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