Thiophene-2-carbonyl-CoA monooxygenase

In enzymology, a thiophene-2-carbonyl-CoA monooxygenase (EC 1.14.99.35) is an enzyme that catalyzes the chemical reaction

thiophene-2-carbonyl-CoA + AH₂ + O₂ ${\displaystyle \rightleftharpoons }$ 5-hydroxythiophene-2-carbonyl-CoA + A + H₂O

thiophene-2-carbonyl-CoA monooxygenase
Identifiers
EC no.	1.14.99.35
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The three substrates of this enzyme are thiophene-2-carbonyl-CoA, an electron acceptor AH₂, and O₂. Its three products are 5-hydroxythiophene-2-carbonyl-CoA, the reduction product A, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O₂ as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O miscellaneous. The systematic name of this enzyme class is thiophene-2-carbonyl-CoA, hydrogen-donor:oxygen oxidoreductase. Other names in common use include thiophene-2-carboxyl-CoA dehydrogenase, thiophene-2-carboxyl-CoA hydroxylase, and thiophene-2-carboxyl-CoA monooxygenase.