Thomas Bruice

Thomas C. Bruice (August 25, 1925 – February 15, 2019)^[1] was a professor of chemistry and biochemistry at University of California, Santa Barbara. He was elected to the National Academy of Sciences in 1974. He was a pioneering researcher in the area of chemical biology, and is one of the 50 most cited chemists.^[2][3]

Thomas C. Bruice
Born	(1925-08-25)August 25, 1925
Died	February 15, 2019(2019-02-15) (aged 93)
Nationality	American
Education	University of Southern California (B.S., Ph.D.)
Known for	Use of imidazole-catalysed hydrolysis of p-nitrophenyl acetate as a model system
Awards	NAS Award in Chemical Sciences
Scientific career
Fields	Bioorganic chemistry, enzyme catalysis
Institutions	University of California, Los Angeles, Yale University, Johns Hopkins University, Cornell University, University of California, Santa Barbara

Education

Bruice earned his B.S. at the University of Southern California, and returned there after his service as a Marine medical corpsman during the World War II island campaigns in the South Pacific, and obtained his Ph.D. there.^[1] He carried out post-doctoral work at University of California, Los Angeles. He has been a faculty member at Yale University, Johns Hopkins University, and Cornell University.^[2] He joined the faculty at the University of California, Santa Barbara in 1964.

Research

Papers

Bruice published more than 600 papers during his career. He saw himself as a bioorganic chemist rather than as a biochemist, and that description is very apt for his work, as most of the molecules that he studied were natural products such as thyroxine.^[4] In addition, he made important contributions to understanding enzyme catalysis, and he pioneered the use of imidazole-catalysed hydrolysis of p-nitrophenyl acetate as a model system.^[5] (This system has the practical advantage that it is very convenient to follow the hydrolysis spectrophotometically.) He also stied^{[check spelling]} a similar reaction catalysed by the enzyme ribonuclease.^[6] More generally, he made a study of mechanisms for chymotrypsin catalysis.,^[7] and in particular the "charge-relay" system as a way of understanding the role of the catalytic triad that exists in such enzymes.^[8] He considered that "orbital steering" was a new name for a well established observation.^[9][10]

Reviews

Bruice wrote reviews on a number of topics, including the use of small molecules to understand catalysis ^[11] and the chemistry of flavins,^[12][13] and on enzyme catalysis in general.^[14]

Books

Bruice collaborated with Stephen Benkovic to write a two-volume work on Bioorganic Mechanisms that helped establish this field.^[15]

Awards and honors

• 2008 - Linus Pauling Award^[16]
• 2005 - NAS Award in Chemical Sciences^[17][18]
• 1978 - Tolman Award^[19]