Thymidine-triphosphatase

In enzymology, a thymidine-triphosphatase (EC 3.6.1.39) is an enzyme that catalyzes the chemical reaction

dTTP + H₂O ${\displaystyle \rightleftharpoons }$ dTDP + phosphate

thymidine-triphosphatase
Identifiers
EC no.	3.6.1.39
CAS no.	37367-74-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are dTTP and H₂O, whereas its two products are dTDP and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is dTTP nucleotidohydrolase. Other names in common use include thymidine triphosphate nucleotidohydrolase, dTTPase, and deoxythymidine-5'-triphosphatase. This enzyme participates in pyrimidine metabolism.