Thyroid-hormone transaminase

In enzymology, a thyroid-hormone transaminase (EC 2.6.1.26) is an enzyme that catalyzes the chemical reaction

L-3,5,3'-triiodothyronine + 2-oxoglutarate ${\displaystyle \rightleftharpoons }$ 3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate + L-glutamate

Thyroid-hormone transaminase
Identifiers
EC no.	2.6.1.26
CAS no.	51004-29-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are L-3,5,3'-triiodothyronine and 2-oxoglutarate, whereas its two products are [[3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate]] and L-glutamate.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-3,5,3'-triiodothyronine:2-oxoglutarate aminotransferase. Other names in common use include 3,5-dinitrotyrosine transaminase, and thyroid hormone aminotransferase. It employs one cofactor, pyridoxal phosphate.