Outer membrane efflux protein

The outer membrane efflux protein is a protein family member that forms trimeric (three-piece) channels allowing the export of a variety of substrates in gram-negative bacteria. Each efflux protein is composed of two repeats. The trimeric channel is composed of a 12-stranded beta-barrel that spans the outer membrane, and a long tail helical barrel that spans the periplasm.

Outer membrane efflux protein
Identifiers
Symbol	OEP
Pfam	PF02321
InterPro	IPR003423
SCOP2	1ek9 / SCOPe / SUPFAM
TCDB	1.B.17
OPM superfamily	34
OPM protein	1yc9
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Examples include the Escherichia coli TolC outer membrane protein, which is required for proper expression of outer membrane protein genes; the Rhizobium nodulation protein; and the Pseudomonas FusA protein, which is involved in resistance to fusaric acid.

References

• Johnson JM, Church GM (April 1999). "Alignment and structure prediction of divergent protein families: periplasmic and outer membrane proteins of bacterial efflux pumps". Journal of Molecular Biology. 287 (3): 695–715. CiteSeerX 10.1.1.73.559. doi:10.1006/jmbi.1999.2630. PMID 10092468.